韩飞

姓名：韩飞

性别：男

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职称/职务：副教授/

个人情况介绍、概览

韩飞，男，博士，副研究员，硕士生导师。2003年毕业于澳门新莆京7906not，获药学（日语）学士学位；2005-2008年于澳门新莆京7906not药剂系硕博连读，获药剂学博士学位；毕业后于沈阳药大药业有限责任公司工作，曾任公司研发总监兼生产总监。2012年，于澳门新莆京7906not分析测试中心任教；2016年，被直聘为澳门新莆京7906not副研究员，主要研究方向为傅立叶变换离子回旋共振质谱法和质谱成像技术在药学研究领域的应用。作为课题负责人主持了国家自然科学基金面上项目1项，辽宁省教育厅一般项目1项，教育部新教师博士点基金1项。另外，作为项目骨干成员承担国家自然科学基金青年基金项目1项。目前已在Talanta, Int J. Pharm., RSC Advances, Anal. Bioanal. Chem., J. Chromatogr. B.等期刊发表SCI论文30余篇。

主要研究方向

研究方向一：质谱成像技术在药学研究领域的应用

研究方向二：超高分辨质谱傅立叶变换离子回旋共振质谱在药学研究领域的应用

研究方向三：新型MALDI基质的开发及应用

主持、参与的科研项目

1. 基于高分辨质谱和质谱成像技术的红景天治疗阿尔茨海默病的药效物质基础和作用机制研究，国家自然科学基金面上项目，基金编号81673575（负责人）

2.新型蛋白质药物传递系统脂质植入剂的药物控释机制研究，国家教育部新教师博士点基金，基金编号20132134120003(负责人)

3. 基于代谢组学的红景天治疗阿尔茨海默病的药效物质基础研究，辽宁省教育厅一般项目，基金编号No.2014380 (负责人)

近年来发表代表性论文：

1.Fei Han, Ran Yin, Xin Che, Jing Yuan, Yanan Cui, He Yin, Sanming Li*.Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: Design, characterization and in vivo evaluation. International Journal of Pharmaceutics.439:349– 357 ,2012. (IF=3.994)

2.Fei Han, Yanting Li, Li Ma, Tianfeng Liu, Yawen Wu, Rui Xu, Aihua Song, Ran Yin.A rapid and sensitive UHPLC-FT-ICR MS/MS method for identification of chemical constituents in Rhodiola crenulataextract, rat plasma and rat brain after oral administration. Talanta,2016,160,183-193. (IF=4.035)

3.Fei Han*, Tianfeng Liu, Ran Yin, Xiaoshu Zhang, Li Ma, Rui Xu and Yawen Wu. UHPLC-FT-ICR-MS combined with serum pharmacochemistry for bioactive compounds discovery of Zhi-Zi-Da-Huang-decoction against alcohol-induced hepatotoxicity in rats.RSC Advances.2016, 6,108917-108927. (IF=3.289)

4.Fei Han,Yan-ting Li, Xin-juan Mao,Xiao-shu Zhang,Jiao Guan,Ai-hua Song,Yin Ran. Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry.Analytical and Bioanalytical Chemistry.2016,408(7),1975-1981. (IF=3.125)

5.Fei Han, Yang Dong, Zhen Su, Ran Yin, Aihua Song, Sanming Li. Preparation, characteristics and assessment of a novel gelatin–chitosan sponge scaffold as skin tissue engineering material. International Journal of Pharmaceutics.2014, 476(1-2),124-133. (IF=3.65)

6.Fei Han, Yanting Li, Xinjuan Mao, Rui Xu and Ran Yin. Characterization of chemical constituents in Rhodiola Crenulate by high-performance liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometer.Journal of Mass Spectrometry.2016, 51,363-368. (IF=2.541)

7.Fei Han, Yanting Li, Xiaoshu Zhang, Aihua Song, Heyun Zhu, Ran Yin.A pilot study of direct infusion analysis by FT-ICR MS for rapid differentiation and authentication of traditional Chinese herbal medicines. International Journal of Mass Spectrometry.2016,403,62-67. (IF=2.183)

8.Fei Han, Yanting Li, Xiaoshu Zhang, Aihua Song, Heyun Zhu, Ran Yin.Comparative study of direct injection analysis and liquidchromatography mass spectrometry for identification of chemicalconstituentsin Kudiezi injection by FT-ICR MSInternational Journal of Mass Spectrometry2016,405,32-38. (IF=2.183)

9.Fei Han, Yang Dong, Aihua Song, Ran Yin. Alginate/chitosan based bi-layer composite membrane as potential sustained-release wound dressing containing ciprofloxacin hydrochloride.AppliedSurfaceScience.2014,311,626-634. (IF=2.711)

10. Aihua Song, Xiaoshu Zhang, Yanting Li, Xinjuan Mao,Fei Han*. Effect of liquid-to-solid lipid ratio onCharacterizations of flurbiprofen-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for transdermal administration. Drug Development And Industrial Pharmacy. 2016, 42(8), 1308-1314. (IF=2.429)